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165 lines
8.6 KiB
XML
165 lines
8.6 KiB
XML
<?xml version="1.0" encoding="utf-8" standalone="no"?>
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<mets ID="sort-mets_mets" OBJID="sword-mets" LABEL="DSpace SWORD Item"
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PROFILE="DSpace METS SIP Profile 1.0" xmlns="http://www.loc.gov/METS/"
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xmlns:xlink="http://www.w3.org/1999/xlink"
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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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xsi:schemaLocation="http://www.loc.gov/METS/ http://www.loc.gov/standards/mets/mets.xsd">
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<metsHdr CREATEDATE="2007-09-01T00:00:00">
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<agent ROLE="CUSTODIAN" TYPE="ORGANIZATION">
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<name>Richard Jones</name>
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</agent>
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</metsHdr>
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<dmdSec ID="sword-mets-dmd-1" GROUPID="sword-mets-dmd-1_group-1">
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<mdWrap LABEL="SWAP Metadata" MDTYPE="OTHER" OTHERMDTYPE="EPDCX"
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MIMETYPE="text/xml">
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<xmlData>
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<epdcx:descriptionSet
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xmlns:epdcx="http://purl.org/eprint/epdcx/2006-11-16/"
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xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
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xsi:schemaLocation="http://purl.org/eprint/epdcx/2006-11-16/ http://purl.org/eprint/epdcx/xsd/2006-11-16/epdcx.xsd">
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<epdcx:description
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epdcx:resourceId="sword-mets-epdcx-1">
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/type"
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epdcx:valueURI="http://purl.org/eprint/entityType/ScholarlyWork"/>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/title">
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<epdcx:valueString>
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Attempts to detect retrotransposition
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and de novo deletion of Alus and other
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dispersed repeats at specific loci in
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the human genome
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/terms/abstract">
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<epdcx:valueString>
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Dispersed repeat elements contribute to
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genome instability by de novo insertion
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and unequal recombination between
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repeats. To study the dynamics of these
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processes, we have developed single DNA
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molecule approaches to detect de novo
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insertions at a single locus and
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Alu-mediated deletions at two different
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loci in human genomic DNA. Validation
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experiments showed these approaches
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could detect insertions and deletions at
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frequencies below 10(-6) per cell.
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However, bulk analysis of germline
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(sperm) and somatic DNA showed no
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evidence for genuine mutant molecules,
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placing an upper limit of insertion and
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deletion rates of 2 x 10(-7) and 3 x
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10(-7), respectively, in the individuals
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tested. Such re-arrangements at these
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loci therefore occur at a rate lower
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than that detectable by the most
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sensitive methods currently available.
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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<epdcx:valueString>
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Hollies, C.R.
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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<epdcx:valueString>
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Monckton, D.G.
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/creator">
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<epdcx:valueString>
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Jeffreys, A.J.
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/identifier">
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<epdcx:valueString
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epdcx:sesURI="http://purl.org/dc/terms/URI">
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http://www.myu.ac.uk/some/identifier
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/eprint/terms/isExpressedAs"
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epdcx:valueRef="sword-mets-expr-1"/>
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</epdcx:description>
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<epdcx:description
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epdcx:resourceId="sword-mets-expr-1">
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/type"
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epdcx:valueURI="http://purl.org/eprint/entityType/Expression"/>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/language"
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epdcx:vesURI="http://purl.org/dc/terms/RFC3066">
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<epdcx:valueString>en</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/elements/1.1/type"
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epdcx:vesURI="http://purl.org/eprint/terms/Type"
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epdcx:valueURI="http://purl.org/eprint/type/JournalArticle"/>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/dc/terms/available">
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<epdcx:valueString
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epdcx:sesURI="http://purl.org/dc/terms/W3CDTF">
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2001-02
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</epdcx:valueString>
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</epdcx:statement>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/eprint/terms/status"
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epdcx:vesURI="http://purl.org/eprint/terms/Status"
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epdcx:valueURI="http://purl.org/eprint/status/PeerReviewed"/>
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<epdcx:statement
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epdcx:propertyURI="http://purl.org/eprint/terms/copyrightHolder">
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<epdcx:valueString>
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Nature Publishing Group
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</epdcx:valueString>
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</epdcx:statement>
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</epdcx:description>
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</epdcx:descriptionSet>
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</xmlData>
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</mdWrap>
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</dmdSec>
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<fileSec>
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<fileGrp ID="sword-mets-fgrp-1" USE="CONTENT">
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<file GROUPID="sword-mets-fgid-0" ID="sword-mets-file-1"
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MIMETYPE="application/pdf">
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<FLocat LOCTYPE="URL" xlink:href="pdf1.pdf"/>
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</file>
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<file GROUPID="sword-mets-fgid-1" ID="sword-mets-file-2"
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MIMETYPE="application/pdf">
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<FLocat LOCTYPE="URL" xlink:href="pdf2.pdf"/>
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</file>
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<file GROUPID="sword-mets-fgid-2" ID="sword-mets-file-3"
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MIMETYPE="application/pdf">
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<FLocat LOCTYPE="URL" xlink:href="pdf3.pdf"/>
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</file>
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</fileGrp>
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</fileSec>
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<structMap ID="sword-mets-struct-1" LABEL="structure"
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TYPE="LOGICAL">
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<div ID="sword-mets-div-1" DMDID="sword-mets-dmd-1" TYPE="SWORD Object">
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<div ID="sword-mets-div-2" TYPE="File">
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<fptr FILEID="sword-mets-file-1"/>
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</div>
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<div ID="sword-mets-div-3" TYPE="File">
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<fptr FILEID="sword-mets-file-2"/>
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</div>
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<div ID="sword-mets-div-4" TYPE="File">
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<fptr FILEID="sword-mets-file-3"/>
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</div>
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</div>
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</structMap>
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</mets>
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