diff --git a/src/app/core/dspace-rest-v2/mocks/mock-submission-response.json b/src/app/core/dspace-rest-v2/mocks/mock-submission-response.json
index 200438d3a0..49f8713df8 100644
--- a/src/app/core/dspace-rest-v2/mocks/mock-submission-response.json
+++ b/src/app/core/dspace-rest-v2/mocks/mock-submission-response.json
@@ -10,7 +10,7 @@
           },
           "label": "Journal Issue",
           "mandatory": true,
-          "repeatable": false,
+          "repeatable": true,
           "mandatoryMessage": "Required field!",
           "hints": "Select a journal issue for this publication.",
           "selectableMetadata": [
diff --git a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.html b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.html
index 433501504c..c532cd9575 100644
--- a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.html
+++ b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.html
@@ -6,8 +6,9 @@
     </button>
 </div>
 <div class="modal-body" *ngVar="(resultsRD$ | async) as resultsRD">
-    <form class="input-group mb-3" #queryForm="ngForm" (ngSubmit)="search(queryForm.value.query)" >
-        <input type="text" class="form-control" name="query" placeholder="Search query" [ngModel]="searchQuery">
+    <form class="input-group mb-3" #queryForm="ngForm" (ngSubmit)="search(queryForm.value.query)">
+        <input type="text" class="form-control" name="query" placeholder="Search query"
+               [ngModel]="searchQuery">
         <div class="input-group-append">
             <button class="btn btn-outline-secondary" type="submit">Go</button>
         </div>
@@ -25,16 +26,13 @@
                         -->
                         <input *ngIf="!isAllSelected() && !isSomeSelected()" type="checkbox"
                                [indeterminate]="false"
-                               (change)="selectAll()"
-                        >
+                               (change)="selectAll()">
                         <input *ngIf="!isAllSelected() && isSomeSelected()" type="checkbox"
                                [indeterminate]="true"
-                               (change)="deselectAll()"
-                        >
+                               (change)="deselectAll()">
                         <input *ngIf="isAllSelected()" type="checkbox"
                                [checked]="true"
-                               (change)="deselectAll()"
-                        >
+                               (change)="deselectAll()">
                     </div>
                 </div>
                 <div ngbDropdown class="input-group-append">
@@ -69,6 +67,7 @@
                        [name]="'checkbox' + i"
                        [id]="'object'+i"
                        [checked]="isSelected(result.indexableObject)"
+                       [disabled]="isDisabled(result.indexableObject)"
                        (change)="selectCheckbox($event.currentTarget.checked, result.indexableObject)">
                 <input *ngIf="!repeatable" class="form-check-input" type="radio"
                        [name]="'radio' + i"
diff --git a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.ts b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.ts
index ba289dda20..90495bfe97 100644
--- a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.ts
+++ b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation-modal.component.ts
@@ -29,6 +29,7 @@ export class DsDynamicLookupRelationModalComponent implements OnInit {
   searchConfig: PaginatedSearchOptions;
   repeatable: boolean;
   selection: DSpaceObject[] = [];
+  previousSelection: DSpaceObject[] = [];
   allSelected = false;
   searchQuery;
   initialPagination = Object.assign(new PaginationComponentOptions(), {
@@ -75,7 +76,12 @@ export class DsDynamicLookupRelationModalComponent implements OnInit {
   }
 
   isSelected(dso: DSpaceObject): boolean {
-    return hasValue(this.selection.find((selected) => selected.uuid === dso.uuid));
+    const completeSelection = [...this.selection, ...this.previousSelection];
+    return hasValue(completeSelection.find((selected) => selected.uuid === dso.uuid));
+  }
+
+  isDisabled(dso: DSpaceObject): boolean {
+    return hasValue(this.previousSelection.find((selected) => selected.uuid === dso.uuid));
   }
 
   selectCheckbox(value: boolean, dso: DSpaceObject) {
@@ -98,7 +104,8 @@ export class DsDynamicLookupRelationModalComponent implements OnInit {
   selectPage(page: SearchResult<DSpaceObject>[]) {
     const newObjects: DSpaceObject[] = page
       .map((searchResult) => searchResult.indexableObject)
-      .filter((dso) => hasNoValue(this.selection.find((selected) => selected.uuid === dso.uuid)));
+      .filter((dso) => hasNoValue(this.selection.find((selected) => selected.uuid === dso.uuid)))
+      .filter((dso) => hasNoValue(this.previousSelection.find((object) => object.uuid === dso.uuid)));
     this.selection = [...this.selection, ...newObjects]
   }
 
@@ -119,11 +126,13 @@ export class DsDynamicLookupRelationModalComponent implements OnInit {
     const fullSearchConfig = Object.assign(this.searchConfig, { pagination: fullPagination });
     const results = this.searchService.search(fullSearchConfig);
     results.pipe(
-        getSucceededRemoteData(),
-        map((resultsRD) => resultsRD.payload.page)
-      )
+      getSucceededRemoteData(),
+      map((resultsRD) => resultsRD.payload.page)
+    )
       .subscribe((results) =>
-        this.selection = [...this.selection, ...results.map((searchResult) => searchResult.indexableObject)]
+        this.selection = results
+          .map((searchResult) => searchResult.indexableObject)
+          .filter((dso) => hasNoValue(this.previousSelection.find((object) => object.uuid === dso.uuid)))
       );
   }
 
diff --git a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation.component.ts b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation.component.ts
index f1d70ee453..88e1e974eb 100644
--- a/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation.component.ts
+++ b/src/app/shared/form/builder/ds-dynamic-form-ui/models/lookup-relation/dynamic-lookup-relation.component.ts
@@ -47,6 +47,8 @@ export class DsDynamicLookupRelationComponent extends DynamicFormControlComponen
   openLookup() {
     this.modalRef = this.modalService.open(DsDynamicLookupRelationModalComponent);
     this.modalRef.componentInstance.repeatable = this.model.repeatable;
+    this.modalRef.componentInstance.selection = this.selectedResults || [];
+    this.modalRef.componentInstance.previousSelection = this.model.value || [];
     this.modalRef.componentInstance.relationKey = this.model.name;
     this.modalRef.result.then((resultList) => {
       this.selectedResults = resultList;