diff --git a/src/app/core/data/relationship-data.service.spec.ts b/src/app/core/data/relationship-data.service.spec.ts
index 4432d5213a..625e0d62f4 100644
--- a/src/app/core/data/relationship-data.service.spec.ts
+++ b/src/app/core/data/relationship-data.service.spec.ts
@@ -125,7 +125,8 @@ describe('RelationshipDataService', () => {
 
   const itemService = jasmine.createSpyObj('itemService', {
     findById: (uuid) => createSuccessfulRemoteDataObject(relatedItems.find((relatedItem) => relatedItem.id === uuid)),
-    findByHref: createSuccessfulRemoteDataObject$(relatedItems[0])
+    findByHref: createSuccessfulRemoteDataObject$(relatedItems[0]),
+    getIDHrefObs: (uuid: string) => observableOf(`https://demo.dspace.org/server/api/core/items/${uuid}`),
   });
 
   function initTestService() {
@@ -240,6 +241,16 @@ describe('RelationshipDataService', () => {
     });
   });
 
+  describe('searchByItemsAndType', () => {
+    it('should call addDependency for each item to invalidate the request when one of the items is update', () => {
+      spyOn(service as any, 'addDependency');
+
+      service.searchByItemsAndType(relationshipType.id, item.id, relationshipType.leftwardType, ['item-id-1', 'item-id-2']);
+
+      expect((service as any).addDependency).toHaveBeenCalledTimes(2);
+    });
+  });
+
   describe('resolveMetadataRepresentation', () => {
     const parentItem: Item = Object.assign(new Item(), {
       id: 'parent-item',
diff --git a/src/app/core/data/relationship-data.service.ts b/src/app/core/data/relationship-data.service.ts
index a7ab4eb31c..e3776d9bca 100644
--- a/src/app/core/data/relationship-data.service.ts
+++ b/src/app/core/data/relationship-data.service.ts
@@ -555,13 +555,18 @@ export class RelationshipDataService extends IdentifiableDataService<Relationshi
       );
     });
 
-    return this.searchBy(
+    const searchRD$: Observable<RemoteData<PaginatedList<Relationship>>> = this.searchBy(
       'byItemsAndType',
       {
         searchParams: searchParams
       },
     ) as Observable<RemoteData<PaginatedList<Relationship>>>;
 
+    arrayOfItemIds.forEach((itemId: string) => {
+      this.addDependency(searchRD$, this.itemService.getIDHrefObs(encodeURIComponent(itemId)));
+    });
+
+    return searchRD$;
   }
 
   /**
diff --git a/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.spec.ts b/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.spec.ts
index 6ca7f57739..ef66f91691 100644
--- a/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.spec.ts
+++ b/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.spec.ts
@@ -185,6 +185,7 @@ describe('EditItemRelationshipsService', () => {
 
       expect(itemService.invalidateByHref).toHaveBeenCalledWith(currentItem.self);
       expect(itemService.invalidateByHref).toHaveBeenCalledWith(relationshipItem1.self);
+      expect(itemService.invalidateByHref).toHaveBeenCalledWith(relationshipItem2.self);
 
       expect(notificationsService.success).toHaveBeenCalledTimes(1);
     });
diff --git a/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.ts b/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.ts
index f14e95f66f..a3d45d6c70 100644
--- a/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.ts
+++ b/src/app/item-page/edit-item-page/item-relationships/edit-item-relationships.service.ts
@@ -61,7 +61,17 @@ export class EditItemRelationshipsService {
       // process each update one by one, while waiting for the previous to finish
       concatMap((update: FieldUpdate) => {
         if (update.changeType === FieldChangeType.REMOVE) {
-          return this.deleteRelationship(update.field as DeleteRelationship).pipe(take(1));
+          return this.deleteRelationship(update.field as DeleteRelationship).pipe(
+            take(1),
+            switchMap((deleteRD: RemoteData<NoContent>) => {
+              if (deleteRD.hasSucceeded) {
+                return this.itemService.invalidateByHref((update.field as DeleteRelationship).relatedItem._links.self.href).pipe(
+                  map(() => deleteRD),
+                );
+              }
+              return [deleteRD];
+            }),
+          );
         } else if (update.changeType === FieldChangeType.ADD) {
           return this.addRelationship(update.field as RelationshipIdentifiable).pipe(
             take(1),
diff --git a/src/app/item-page/edit-item-page/item-relationships/edit-relationship-list/edit-relationship-list.component.ts b/src/app/item-page/edit-item-page/item-relationships/edit-relationship-list/edit-relationship-list.component.ts
index c105f0ef93..f57859220a 100644
--- a/src/app/item-page/edit-item-page/item-relationships/edit-relationship-list/edit-relationship-list.component.ts
+++ b/src/app/item-page/edit-item-page/item-relationships/edit-relationship-list/edit-relationship-list.component.ts
@@ -33,6 +33,7 @@ import {
 } from '../../../../core/shared/item-relationships/relationship-type.model';
 import {
   getAllSucceededRemoteData,
+  getFirstCompletedRemoteData,
   getFirstSucceededRemoteData,
   getFirstSucceededRemoteDataPayload,
   getRemoteDataPayload,
@@ -334,6 +335,7 @@ export class EditRelationshipListComponent implements OnInit, OnDestroy {
                       type: this.relationshipType,
                       originalIsLeft: isLeft,
                       originalItem: this.item,
+                      relatedItem,
                       relationship,
                     } as RelationshipIdentifiable;
                     return this.objectUpdatesService.saveRemoveFieldUpdate(this.url,update);
@@ -483,10 +485,24 @@ export class EditRelationshipListComponent implements OnInit, OnDestroy {
             this.relationshipService.isLeftItem(relationship, this.item).pipe(
               // emit an array containing both the relationship and whether it's the left item,
               // as we'll need both
-              map((isLeftItem: boolean) => [relationship, isLeftItem])
-            )
+              switchMap((isLeftItem: boolean) => {
+                if (isLeftItem) {
+                  return relationship.rightItem.pipe(
+                    getFirstCompletedRemoteData(),
+                    getRemoteDataPayload(),
+                    map((relatedItem: Item) => [relationship, isLeftItem, relatedItem]),
+                  );
+                } else {
+                  return relationship.leftItem.pipe(
+                    getFirstCompletedRemoteData(),
+                    getRemoteDataPayload(),
+                    map((relatedItem: Item) => [relationship, isLeftItem, relatedItem]),
+                  );
+                }
+              }),
+            ),
           ),
-          map(([relationship, isLeftItem]: [Relationship, boolean]) => {
+          map(([relationship, isLeftItem, relatedItem]: [Relationship, boolean, Item]) => {
             // turn it into a RelationshipIdentifiable, an
             const nameVariant =
               isLeftItem ? relationship.rightwardValue : relationship.leftwardValue;
@@ -496,6 +512,7 @@ export class EditRelationshipListComponent implements OnInit, OnDestroy {
               relationship,
               originalIsLeft: isLeftItem,
               originalItem: this.item,
+              relatedItem: relatedItem,
               nameVariant,
             } as RelationshipIdentifiable;
           }),